Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

Hepatic steatosis is caused by metabolic imbalances that could be explained in part by an increase in de novo lipogenesis that results from increased sterol element binding protein 1 (SREBP-1) activity. The nuclear receptor liver receptor homolog 1 (LRH-1) is an important regulator of intermediary m...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Stein, Sokrates, Lemos, Vera, Xu, Pan, Demagny, Hadrien, Wang, Xu, Ryu, Dongryeol, Jimenez, Veronica, Bosch, Fatima, Lüscher, Thomas F., Oosterveer, Maaike H., Schoonjans, Kristina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5272172/
https://ncbi.nlm.nih.gov/pubmed/28094767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85499
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