Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

Hepatic steatosis is caused by metabolic imbalances that could be explained in part by an increase in de novo lipogenesis that results from increased sterol element binding protein 1 (SREBP-1) activity. The nuclear receptor liver receptor homolog 1 (LRH-1) is an important regulator of intermediary m...

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Pubblicato in:J Clin Invest
Autori principali: Stein, Sokrates, Lemos, Vera, Xu, Pan, Demagny, Hadrien, Wang, Xu, Ryu, Dongryeol, Jimenez, Veronica, Bosch, Fatima, Lüscher, Thomas F., Oosterveer, Maaike H., Schoonjans, Kristina
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5272172/
https://ncbi.nlm.nih.gov/pubmed/28094767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85499
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