Affinity Maturation of a Cyclic Peptide Handle for Therapeutic Antibodies Using Deep Mutational Scanning

Meditopes are cyclic peptides that bind in a specific pocket in the antigen-binding fragment of a therapeutic antibody such as cetuximab. Provided their moderate affinity can be enhanced, meditope peptides could be used as specific non-covalent and paratope-independent handles in targeted drug deliv...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: van Rosmalen, Martijn, Janssen, Brian M. G., Hendrikse, Natalie M., van der Linden, Ardjan J., Pieters, Pascal A., Wanders, Dave, de Greef, Tom F. A., Merkx, Maarten
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270489/
https://ncbi.nlm.nih.gov/pubmed/27974464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.764225
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