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Tuning the Flexibility of Glycine-Serine Linkers To Allow Rational Design of Multidomain Proteins

[Image: see text] Flexible polypeptide linkers composed of glycine and serine are important components of engineered multidomain proteins. We have previously shown that the conformational properties of Gly-Gly-Ser repeat linkers can be quantitatively understood by comparing experimentally determined...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: van Rosmalen, Martijn, Krom, Mike, Merkx, Maarten
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150656/
https://ncbi.nlm.nih.gov/pubmed/29168376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00902
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