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Design and characterization of structured protein linkers with differing flexibilities

Engineered fusion proteins containing two or more functional polypeptides joined by a peptide or protein linker are important for many fields of biological research. The separation distance between functional units can impact epitope access and the ability to bind with avidity; thus the availability...

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Bibliografiske detaljer
Main Authors: Klein, Joshua S., Jiang, Siduo, Galimidi, Rachel P., Keeffe, Jennifer R., Bjorkman, Pamela J.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191447/
https://ncbi.nlm.nih.gov/pubmed/25301959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzu043
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