Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation

Osteoporosis is caused by a disequilibrium between bone resorption and bone formation. Therapeutics for osteoporosis can be divided into antiresorptives that suppress bone resorption and anabolics which increase bone formation. Currently, the only anabolic treatment options are parathyroid hormone m...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bashiruddin, Nasir K., Hayashi, Mikihito, Nagano, Masanobu, Wu, Yan, Matsunaga, Yukiko, Takagi, Junichi, Nakashima, Tomoki, Suga, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733813/
https://ncbi.nlm.nih.gov/pubmed/33229551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012266117
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