Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation

Osteoporosis is caused by a disequilibrium between bone resorption and bone formation. Therapeutics for osteoporosis can be divided into antiresorptives that suppress bone resorption and anabolics which increase bone formation. Currently, the only anabolic treatment options are parathyroid hormone m...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Bashiruddin, Nasir K., Hayashi, Mikihito, Nagano, Masanobu, Wu, Yan, Matsunaga, Yukiko, Takagi, Junichi, Nakashima, Tomoki, Suga, Hiroaki
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733813/
https://ncbi.nlm.nih.gov/pubmed/33229551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012266117
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