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Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation

Osteoporosis is caused by a disequilibrium between bone resorption and bone formation. Therapeutics for osteoporosis can be divided into antiresorptives that suppress bone resorption and anabolics which increase bone formation. Currently, the only anabolic treatment options are parathyroid hormone m...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Bashiruddin, Nasir K., Hayashi, Mikihito, Nagano, Masanobu, Wu, Yan, Matsunaga, Yukiko, Takagi, Junichi, Nakashima, Tomoki, Suga, Hiroaki
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733813/
https://ncbi.nlm.nih.gov/pubmed/33229551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012266117
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