Prognostic impact of MutT homolog‐1 expression on esophageal squamous cell carcinoma

MutT homolog‐1 (MTH1) is a pyrophosphatase that acts on oxidized nucleotides and hydrolyzes 8‐oxo‐2’‐deoxyguanosine triphosphate in deoxynucleoside triphosphate pool to prevent its incorporation into nuclear and mitochondrial DNA, result in reduce cytotoxicity in tumor cells. MTH1 is overexpressed i...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Med
Auteurs principaux: Akiyama, Shingo, Saeki, Hiroshi, Nakashima, Yuichiro, Iimori, Makoto, Kitao, Hiroyuki, Oki, Eiji, Oda, Yoshinao, Nakabeppu, Yusaku, Kakeji, Yoshihiro, Maehara, Yoshihiko
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2016
Sujets:
Cancer Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269568/
https://ncbi.nlm.nih.gov/pubmed/27917618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.979
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