Prognostic impact of MutT homolog‐1 expression on esophageal squamous cell carcinoma

MutT homolog‐1 (MTH1) is a pyrophosphatase that acts on oxidized nucleotides and hydrolyzes 8‐oxo‐2’‐deoxyguanosine triphosphate in deoxynucleoside triphosphate pool to prevent its incorporation into nuclear and mitochondrial DNA, result in reduce cytotoxicity in tumor cells. MTH1 is overexpressed i...

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Bibliografiske detaljer
Udgivet i:Cancer Med
Main Authors: Akiyama, Shingo, Saeki, Hiroshi, Nakashima, Yuichiro, Iimori, Makoto, Kitao, Hiroyuki, Oki, Eiji, Oda, Yoshinao, Nakabeppu, Yusaku, Kakeji, Yoshihiro, Maehara, Yoshihiko
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269568/
https://ncbi.nlm.nih.gov/pubmed/27917618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.979
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