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Prognostic impact of MutT homolog‐1 expression on esophageal squamous cell carcinoma

MutT homolog‐1 (MTH1) is a pyrophosphatase that acts on oxidized nucleotides and hydrolyzes 8‐oxo‐2’‐deoxyguanosine triphosphate in deoxynucleoside triphosphate pool to prevent its incorporation into nuclear and mitochondrial DNA, result in reduce cytotoxicity in tumor cells. MTH1 is overexpressed i...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Akiyama, Shingo, Saeki, Hiroshi, Nakashima, Yuichiro, Iimori, Makoto, Kitao, Hiroyuki, Oki, Eiji, Oda, Yoshinao, Nakabeppu, Yusaku, Kakeji, Yoshihiro, Maehara, Yoshihiko
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269568/
https://ncbi.nlm.nih.gov/pubmed/27917618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.979
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