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Prognostic impact of MutT homolog‐1 expression on esophageal squamous cell carcinoma
MutT homolog‐1 (MTH1) is a pyrophosphatase that acts on oxidized nucleotides and hydrolyzes 8‐oxo‐2’‐deoxyguanosine triphosphate in deoxynucleoside triphosphate pool to prevent its incorporation into nuclear and mitochondrial DNA, result in reduce cytotoxicity in tumor cells. MTH1 is overexpressed i...
Gespeichert in:
| Veröffentlicht in: | Cancer Med |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5269568/ https://ncbi.nlm.nih.gov/pubmed/27917618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.979 |
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