High ubiquitin‐specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer

Chromosomal instability (CIN), characterized by aneuploidy, is a major molecular subtype of gastric cancer. The deubiquitinase USP44 is an important regulator of APC activation in the spindle checkpoint and leads to proper chromosome separation to prevent aneuploidy. Aberrant expression of USP44 lea...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Med
Hauptverfasser: Nishimura, Sho, Oki, Eiji, Ando, Koji, Iimori, Makoto, Nakaji, Yu, Nakashima, Yuichiro, Saeki, Hiroshi, Oda, Yoshinao, Maehara, Yoshihiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Cancer Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5463085/
https://ncbi.nlm.nih.gov/pubmed/28544703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1090
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