Differences in Vector Genome Processing and Illegitimate Integration of Non-Integrating Lentiviral Vectors

A variety of mutations in lentiviral vector expression systems have been shown to generate a non-integrating phenotype. We studied a novel 12 base-pair U3-LTR integrase attachment site deletion (U3-LTR att site) mutant and found similar physical titers to the previously reported integrase catalytic...

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Udgivet i:Gene Ther
Main Authors: Shaw, Aaron M., Joseph, Guiandre L., Jasti, Aparna C., Sastry-Dent, Lakshmi, Witting, Scott, Cornetta, Kenneth
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269419/
https://ncbi.nlm.nih.gov/pubmed/27682478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2016.69
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