Notable Reduction in Illegitimate Integration Mediated by a PPT-deleted, Nonintegrating Lentiviral Vector

Nonintegrating lentiviral vectors present a means of reducing the risk of insertional mutagenesis in nondividing cells and enabling short-term expression of potentially hazardous gene products. However, residual, integrase-independent integration raises a concern that may limit the usefulness of thi...

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Main Authors: Kantor, Boris, Bayer, Matthew, Ma, Hong, Samulski, Jude, Li, Chengwen, McCown, Thomas, Kafri, Tal
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048187/
https://ncbi.nlm.nih.gov/pubmed/21157436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.277
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