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Transgenic sheep generated by lentiviral vectors: safety and integration analysis of surrogates and their offspring

The safety of HIV-1 based vectors was evaluated during the production of transgenic sheep. Vectors were introduced into the perivitelline space of in vivo derived one-cell sheep embryos by microinjection then transferred into the oviducts of recipient females. At 60–70 days of gestation, a portion o...

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Autors principals: Cornetta, Kenneth, Tessanne, Kimberly, Long, Charles, Yao, Jing, Satterfield, Carey, Westhusin, Mark
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606283/
https://ncbi.nlm.nih.gov/pubmed/23180364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11248-012-9674-3
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