Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants

The age-dependent absolute protein abundance of carboxylesterase (CES) 1 and CES2 in human liver was investigated and applied to predict infant pharmacokinetics (PK) of oseltamivir. The CES absolute protein abundance was determined by liquid chromatography-tandem mass spectrometry proteomics in huma...

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Veröffentlicht in:Drug Metab Dispos
Hauptverfasser: Boberg, Mikael, Vrana, Marc, Mehrotra, Aanchal, Pearce, Robin E., Gaedigk, Andrea, Bhatt, Deepak Kumar, Leeder, J. Steven, Prasad, Bhagwat
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2017
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5267516/
https://ncbi.nlm.nih.gov/pubmed/27895113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.072652
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