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SHP-1: the next checkpoint target for cancer immunotherapy?

The immense power of the immune system is harnessed in healthy individuals by a range of negative regulatory signals and checkpoints. Manipulating these checkpoints through inhibition has resulted in striking immune-mediated clearance of otherwise untreatable tumours and metastases; unfortunately, n...

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Detalhes bibliográficos
Publicado no:Biochem Soc Trans
Main Authors: Watson, H. Angharad, Wehenkel, Sophie, Matthews, James, Ager, Ann
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264497/
https://ncbi.nlm.nih.gov/pubmed/27068940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20150251
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