Purity of transferred CD8(+) T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1

Adoptive transfer of tumor-specific cytotoxic T cells is a promising advance in cancer therapy. Similarly, checkpoint inhibition has shown striking clinical results in some patients. Here we combine adoptive cell transfer with ablation of the checkpoint protein Src homology 2-domain-containing phosp...

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Detalhes bibliográficos
Publicado no:Immunol Cell Biol
Main Authors: Watson, H Angharad, Dolton, Garry, Ohme, Julia, Ladell, Kristin, Vigar, Miriam, Wehenkel, Sophie, Hindley, James, Mohammed, Rebar N, Miners, Kelly, Luckwell, Rhys A, Price, David A, Matthews, R James, Ager, Ann
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027373/
https://ncbi.nlm.nih.gov/pubmed/27430370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2016.45
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