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Homing to solid cancers: a vascular checkpoint in adoptive cell therapy using CAR T-cells

The success of adoptive T-cell therapies for the treatment of cancer patients depends on transferred T-lymphocytes finding and infiltrating cancerous tissues. For intravenously transferred T-cells, this means leaving the bloodstream (extravasation) from tumour blood vessels. In inflamed tissues, a k...

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Detalhes bibliográficos
Publicado no:Biochem Soc Trans
Main Authors: Ager, Ann, Watson, H. Angharad, Wehenkel, Sophie C., Mohammed, Rebar N.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264496/
https://ncbi.nlm.nih.gov/pubmed/27068943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20150254
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