Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells

Increased breast density attributed to collagen I deposition is associated with a 4–6 fold increased risk of developing breast cancer. Here, we assessed cellular metabolic reprogramming of mammary carcinoma cells in response to increased collagen matrix density using an in vitro 3D model. Our initia...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Morris, Brett A., Burkel, Brian, Ponik, Suzanne M., Fan, Jing, Condeelis, John S., Aguire-Ghiso, Julio A., Castracane, James, Denu, John M., Keely, Patricia J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264313/
https://ncbi.nlm.nih.gov/pubmed/27743905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.10.012
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