Rapidly cycling Lgr5(+) stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk

The majority of colon tumors are driven by aberrant Wnt signaling in intestinal stem cells, which mediates an efficient route toward initiating intestinal cancer. Natural lipophilic polyphenols and long-chain polyunsaturated fatty acids (PUFAs) generally suppress Wnt- and NF-κB- (nuclear factor-κ li...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Kim, Eunjoo, Davidson, Laurie A, Zoh, Roger S, Hensel, Martha E, Salinas, Michael L, Patil, Bhimanagouda S, Jayaprakasha, Guddadarangavvanahally K, Callaway, Evelyn S, Allred, Clinton D, Turner, Nancy D, Weeks, Brad R, Chapkin, Robert S
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260883/
https://ncbi.nlm.nih.gov/pubmed/27831561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.269
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