Rapidly cycling Lgr5(+) stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk

The majority of colon tumors are driven by aberrant Wnt signaling in intestinal stem cells, which mediates an efficient route toward initiating intestinal cancer. Natural lipophilic polyphenols and long-chain polyunsaturated fatty acids (PUFAs) generally suppress Wnt- and NF-κB- (nuclear factor-κ li...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Kim, Eunjoo, Davidson, Laurie A, Zoh, Roger S, Hensel, Martha E, Salinas, Michael L, Patil, Bhimanagouda S, Jayaprakasha, Guddadarangavvanahally K, Callaway, Evelyn S, Allred, Clinton D, Turner, Nancy D, Weeks, Brad R, Chapkin, Robert S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260883/
https://ncbi.nlm.nih.gov/pubmed/27831561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.269
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