Differential effects of 2- and 3-series E-prostaglandins on in vitro expansion of Lgr5(+) colonic stem cells

Arachidonic acid (20:4(∆5,8,11,14), AA)-derived prostaglandin E(2) (PGE(2)) promotes colon cancer development. In contrast, chemoprotective n-3 polyunsaturated fatty acids supplant AA, thereby decreasing PGE(2) biosynthesis in colonocytes, with eicosapentaenoic acid (20:5(∆5,8,11,14,17), EPA) in par...

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Bibliografiska uppgifter
Huvudupphovsmän: Fan, Yang-Yi, Davidson, Laurie A., Callaway, Evelyn S., Goldsby, Jennifer S., Chapkin, Robert S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2014
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Original Manuscript
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941743/
https://ncbi.nlm.nih.gov/pubmed/24336194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt412
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