Laddar...

Targeted deletion of p53 in Lgr5-expressing intestinal stem cells promotes colon tumorigenesis in a preclinical model of colitis-associated cancer

p53 has been shown to mediate cancer stem-like cell function by suppressing pluripotency and cellular dedifferentiation. However, there have been no studies to date which have addressed the specific effects of p53 loss in colonic adult stem cells. In this study, we investigated the consequences of c...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Cancer Res
Huvudupphovsmän: Davidson, Laurie A., Callaway, Evelyn, Kim, Eunjoo, Weeks, Brad R., Fan, Yang-Yi, Allred, Clinton D., Chapkin, Robert S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681667/
https://ncbi.nlm.nih.gov/pubmed/26631266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1706
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!