Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells

Glioblastoma (GBM) is the most malignant and lethal brain tumor harboring glioma stem cells (GSCs) that promote tumor propagation and therapeutic resistance. GSCs preferentially express several critical cell surface molecules that regulate the pro-survival signaling for maintaining the stem cell-lik...

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Dettagli Bibliografici
Pubblicato in:Cell Death Differ
Autori principali: Shi, Yu, Zhou, Wenchao, Cheng, Lin, Chen, Cong, Huang, Zhi, Fang, Xiaoguang, Wu, Qiulian, He, Zhicheng, Xu, Senlin, Lathia, Justin D, Ping, Yifang, Rich, Jeremy N, Bian, Xiu-Wu, Bao, Shideng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260495/
https://ncbi.nlm.nih.gov/pubmed/27740621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.110
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