Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells

Glioblastoma (GBM) is the most malignant and lethal brain tumor harboring glioma stem cells (GSCs) that promote tumor propagation and therapeutic resistance. GSCs preferentially express several critical cell surface molecules that regulate the pro-survival signaling for maintaining the stem cell-lik...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Shi, Yu, Zhou, Wenchao, Cheng, Lin, Chen, Cong, Huang, Zhi, Fang, Xiaoguang, Wu, Qiulian, He, Zhicheng, Xu, Senlin, Lathia, Justin D, Ping, Yifang, Rich, Jeremy N, Bian, Xiu-Wu, Bao, Shideng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260495/
https://ncbi.nlm.nih.gov/pubmed/27740621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.110
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