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Novel group-based QSAR and combinatorial design of CK-1δ inhibitors as neuroprotective agents
BACKGROUND: Tar DNA binding protein 43 (TDP-43) hyperphosphorylation, caused by Casein kinase 1 (CK-1) protein isoforms, is associated with the onset and progression of Amyotrophic Lateral Sclerosis (ALS). Among the reported isoforms and splice variants of CK-1 protein superfamily, CK-1δ is known to...
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| Publicado no: | BMC Bioinformatics |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5260052/ https://ncbi.nlm.nih.gov/pubmed/28155653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-016-1379-9 |
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