Hydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations

p53, a tumor suppressor protein, has been proven to regulate the cell cycle, apoptosis, and DNA repair to prevent malignant transformation. MDM2 regulates activity of p53 and inhibits its binding to DNA. In the present study, we elucidated the MDM2 inhibition potential of polyphenols (Apigenin, Fise...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Verma, Sharad, Grover, Sonam, Tyagi, Chetna, Goyal, Sukriti, Jamal, Salma, Singh, Aditi, Grover, Abhinav
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749206/
https://ncbi.nlm.nih.gov/pubmed/26863418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149014
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