Alanine mutation of the catalytic sites of Pantothenate Synthetase causes distinct conformational changes in the ATP binding region

The enzyme Pantothenate synthetase (PS) represents a potential drug target in Mycobacterium tuberculosis. Its X-ray crystallographic structure has demonstrated the significance and importance of conserved active site residues including His44, His47, Asn69, Gln72, Lys160 and Gln164 in substrate bindi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pandey, Bharati, Grover, Sonam, Goyal, Sukriti, Kumari, Anchala, Singh, Aditi, Jamal, Salma, Kaur, Jagdeep, Grover, Abhinav
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772511/
https://ncbi.nlm.nih.gov/pubmed/29343701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-19075-2
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