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Cheminformatics models based on machine learning approaches for design of USP1/UAF1 abrogators as anticancer agents
Cancer cells have upregulated DNA repair mechanisms, enabling them survive DNA damage induced during repeated rapid cell divisions and targeted chemotherapeutic treatments. Cancer cell proliferation and survival targeting via inhibition of DNA repair pathways is currently a very promiscuous anti-tum...
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| Publicado no: | Syst Synth Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Netherlands
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4427583/ https://ncbi.nlm.nih.gov/pubmed/25972987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11693-015-9162-1 |
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