Molecular modeling and lead design of substituted zanamivir derivatives as potent anti-influenza drugs

BACKGROUND: Influenza virus spreads infection by two main surface glycoproteins, namely hemagglutinin (HA) and neuraminidase (NA). NA cleaves the sialic acid receptors eventually releasing newly formed virus particles which then invade new cells. Inhibition of NA could limit the replication of virus...

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Detalhes bibliográficos
Publicado no:BMC Bioinformatics
Main Authors: Dholakia, Dhwani, Goyal, Sukriti, Jamal, Salma, Singh, Aditi, Das, Asmita, Grover, Abhinav
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5259988/
https://ncbi.nlm.nih.gov/pubmed/28155702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-016-1374-1
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