Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography

Nephrin is a key functional component of the slit diaphragm, the structurally unresolved molecular filter in renal glomerular capillaries. Abnormal nephrin or its absence results in severe proteinuria and loss of the slit diaphragm. The diaphragm is a thin extracellular membrane spanning the approxi...

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Main Authors: Wartiovaara, Jorma, Öfverstedt, Lars-Göran, Khoshnoodi, Jamshid, Zhang, Jingjing, Mäkelä, Eetu, Sandin, Sara, Ruotsalainen, Vesa, Cheng, R. Holland, Jalanko, Hannu, Skoglund, Ulf, Tryggvason, Karl
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC525744/
https://ncbi.nlm.nih.gov/pubmed/15545998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200422562
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