Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography

Nephrin is a key functional component of the slit diaphragm, the structurally unresolved molecular filter in renal glomerular capillaries. Abnormal nephrin or its absence results in severe proteinuria and loss of the slit diaphragm. The diaphragm is a thin extracellular membrane spanning the approxi...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wartiovaara, Jorma, Öfverstedt, Lars-Göran, Khoshnoodi, Jamshid, Zhang, Jingjing, Mäkelä, Eetu, Sandin, Sara, Ruotsalainen, Vesa, Cheng, R. Holland, Jalanko, Hannu, Skoglund, Ulf, Tryggvason, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC525744/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15545998/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI22562
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