Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography

Nephrin is a key functional component of the slit diaphragm, the structurally unresolved molecular filter in renal glomerular capillaries. Abnormal nephrin or its absence results in severe proteinuria and loss of the slit diaphragm. The diaphragm is a thin extracellular membrane spanning the approxi...

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Gepubliceerd in:J Clin Invest
Hoofdauteurs: Wartiovaara, Jorma, Öfverstedt, Lars-Göran, Khoshnoodi, Jamshid, Zhang, Jingjing, Mäkelä, Eetu, Sandin, Sara, Ruotsalainen, Vesa, Cheng, R. Holland, Jalanko, Hannu, Skoglund, Ulf, Tryggvason, Karl
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2004
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Article
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC525744/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15545998/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI22562
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