Loss of α-hemoglobin–stabilizing protein impairs erythropoiesis and exacerbates β-thalassemia

Hemoglobin (Hb) A production during red blood cell development is coordinated to minimize the deleterious effects of free α- and β-Hb subunits, which are unstable and cytotoxic. The α-Hb–stabilizing protein (AHSP) is an erythroid protein that specifically binds α-Hb and prevents its precipitation in...

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Autori principali: Kong, Yi, Zhou, Suiping, Kihm, Anthony J., Katein, Anne M., Yu, Xiang, Gell, David A., Mackay, Joel P., Adachi, Kazuhiko, Foster-Brown, Linda, Louden, Calvert S., Gow, Andrew J., Weiss, Mitchell J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC525742/
https://ncbi.nlm.nih.gov/pubmed/15545996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421982
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