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Histone adduction and its functional impact on epigenetics

Bioactive electrophiles generated from the oxidation of endogenous and exogenous compounds are a contributing factor in numerous disease states. Their toxicity is largely attributed to the covalent modification of cellular nucleophiles, including protein and DNA. With regard to protein modification,...

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Bibliographic Details
Published in:Chem Res Toxicol
Main Authors: Galligan, James J., Marnett, Lawrence J.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5257195/
https://ncbi.nlm.nih.gov/pubmed/27930886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00379
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