The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity

Tumors comprise functionally diverse subpopulations of cells with distinct proliferative potential. Here, we show that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long-term cancer growth. Numerous cancer types exhibit high inter-...

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Veröffentlicht in:Science
Hauptverfasser: Torres, Cristina Morales, Biran, Alva, Burney, Matthew J., Patel, Harshil, Henser-Brownhill, Tristan, Cohen, Ayelet-Hashahar Shapira, Li, Yilong, Ben-Hamo, Rotem, Nye, Emma, Spencer-Dene, Bradley, Chakravarty, Probir, Efroni, Sol, Matthews, Nik, Misteli, Tom, Meshorer, Eran, Scaffidi, Paola
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131846/
https://ncbi.nlm.nih.gov/pubmed/27708074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf1644
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