Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling

The tumor suppressor protein Merlin is proteasomally degraded in breast cancer. We undertook an untargeted metabolomics approach to discern the global metabolomics profile impacted by Merlin in breast cancer cells. We discerned specific changes in glutathione metabolites that uncovered novel facets...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Sci Rep
Main Authors: Das, Shamik, Jackson, William P., Prasain, Jeevan K., Hanna, Ann, Bailey, Sarah K., Tucker, J. Allan, Bae, Sejong, Wilson, Landon S., Samant, Rajeev S., Barnes, Stephen, Shevde, Lalita A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2017
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256100/
https://ncbi.nlm.nih.gov/pubmed/28112165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40773
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla