Hedgehog Signaling Induced by Breast Cancer Cells Promotes Osteoclastogenesis and Osteolysis

Bone integrity is maintained by a dynamic equilibrium between the activities of bone-forming osteoblasts and bone-resorbing osteoclasts. Osteolytic lesions are a painful consequence of metastasis of breast cancer cells to bone in an overwhelming majority of breast cancer patients. Factors secreted b...

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Bibliographic Details
Main Authors: Das, Shamik, Samant, Rajeev S., Shevde, Lalita A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058990/
https://ncbi.nlm.nih.gov/pubmed/21169638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.174920
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