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INCREASED VASCULARITY AND SPONTANEOUS METASTASIS OF BREAST CANCER BY HEDGEHOG SIGNALING MEDIATED UPREGULATION OF CYR61

The Hedgehog (Hh) pathway is well known for its involvement in angiogenesis and vasculogenesis during ontogeny. The ligand, Sonic hedgehog (SHH), plays an important role in vascular formation during development. However, SHH expression is upregulated on tumor cells and can impact the tumor microenvi...

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Detalhes bibliográficos
Main Authors: Harris, Lillianne G., Pannell, Lewis K., Singh, Seema, Samant, Rajeev S., Shevde, Lalita A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276742/
https://ncbi.nlm.nih.gov/pubmed/22056874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.496
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