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Nonclassical Activation of Hedgehog Signaling Enhances Multidrug Resistance and Makes Cancer Cells Refractory to Smoothened-targeting Hedgehog Inhibition

The Hedgehog (Hh) pathway is critical in normal development. However, it has been reported to be up-regulated in numerous cancers and implicated in tumorigenicity and metastasis. Classical activation of Hh signaling initiated by Hh ligands results in activation of Smoothened (SMOH) and culminates in...

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Main Authors: Das, Shamik, Samant, Rajeev S., Shevde, Lalita A.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636870/
https://ncbi.nlm.nih.gov/pubmed/23508962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.432302
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