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Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling
The tumor suppressor protein Merlin is proteasomally degraded in breast cancer. We undertook an untargeted metabolomics approach to discern the global metabolomics profile impacted by Merlin in breast cancer cells. We discerned specific changes in glutathione metabolites that uncovered novel facets...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5256100/ https://ncbi.nlm.nih.gov/pubmed/28112165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40773 |
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