A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action

Influenza B virus (IBV) causes annual influenza epidemics around the world. Here we use an in vivo plasmablast enrichment technique to isolate a human monoclonal antibody, 46B8 that neutralizes all IBVs tested in vitro and protects mice against lethal challenge of all IBVs tested when administered 7...

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Udgivet i:Nat Commun
Main Authors: Chai, Ning, Swem, Lee R., Park, Summer, Nakamura, Gerald, Chiang, Nancy, Estevez, Alberto, Fong, Rina, Kamen, Lynn, Kho, Elviza, Reichelt, Mike, Lin, Zhonghua, Chiu, Henry, Skippington, Elizabeth, Modrusan, Zora, Stinson, Jeremy, Xu, Min, Lupardus, Patrick, Ciferri, Claudio, Tan, Man-Wah
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253702/
https://ncbi.nlm.nih.gov/pubmed/28102191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14234
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