A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action

Influenza B virus (IBV) causes annual influenza epidemics around the world. Here we use an in vivo plasmablast enrichment technique to isolate a human monoclonal antibody, 46B8 that neutralizes all IBVs tested in vitro and protects mice against lethal challenge of all IBVs tested when administered 7...

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Publicado en:Nat Commun
Main Authors: Chai, Ning, Swem, Lee R., Park, Summer, Nakamura, Gerald, Chiang, Nancy, Estevez, Alberto, Fong, Rina, Kamen, Lynn, Kho, Elviza, Reichelt, Mike, Lin, Zhonghua, Chiu, Henry, Skippington, Elizabeth, Modrusan, Zora, Stinson, Jeremy, Xu, Min, Lupardus, Patrick, Ciferri, Claudio, Tan, Man-Wah
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253702/
https://ncbi.nlm.nih.gov/pubmed/28102191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14234
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