Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity

The serine/threonine kinase IL-1R–associated kinase (IRAK)4 is a critical regulator of innate immunity. We have identified BMS-986126, a potent, highly selective inhibitor of IRAK4 kinase activity that demonstrates equipotent activity against multiple MyD88-dependent responses both in vitro and in v...

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Pubblicato in:J Immunol
Autori principali: Dudhgaonkar, Shailesh, Ranade, Sourabh, Nagar, Jignesh, Subramani, Siva, Prasad, Durga Shiv, Karunanithi, Preethi, Srivastava, Ratika, Venkatesh, Kamala, Selvam, Sabariya, Krishnamurthy, Prasad, Mariappan, T. Thanga, Saxena, Ajay, Fan, Li, Stetsko, Dawn K., Holloway, Deborah A., Li, Xin, Zhu, Jun, Yang, Wen-Pin, Ruepp, Stefan, Nair, Satheesh, Santella, Joseph, Duncia, John, Hynes, John, McIntyre, Kim W., Carman, Julie A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: AAI 2017
Soggetti:
Innate Immunity and Inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253435/
https://ncbi.nlm.nih.gov/pubmed/28003376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600583
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