Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5

Por Carter, Percy H., Brown, Gregory D., Cherney, Robert J., Batt, Douglas G., Chen, Jing, Clark, Cheryl M., Cvijic, Mary Ellen, Duncia, John V., Ko, Soo S., Mandlekar, Sandhya, Mo, Ruowei, Nelson, David J., Pang, Jian, Rose, Anne V., Santella, Joseph B., Tebben, Andrew J., Traeger, Sarah C., Xu, Songmei, Zhao, Qihong, Barrish, Joel C.
Publicado no ACS Med Chem Lett (2015)

Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity

Por Dudhgaonkar, Shailesh, Ranade, Sourabh, Nagar, Jignesh, Subramani, Siva, Prasad, Durga Shiv, Karunanithi, Preethi, Srivastava, Ratika, Venkatesh, Kamala, Selvam, Sabariya, Krishnamurthy, Prasad, Mariappan, T. Thanga, Saxena, Ajay, Fan, Li, Stetsko, Dawn K., Holloway, Deborah A., Li, Xin, Zhu, Jun, Yang, Wen-Pin, Ruepp, Stefan, Nair, Satheesh, Santella, Joseph, Duncia, John, Hynes, John, McIntyre, Kim W., Carman, Julie A.
Publicado no J Immunol (2017)