Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity

The serine/threonine kinase IL-1R–associated kinase (IRAK)4 is a critical regulator of innate immunity. We have identified BMS-986126, a potent, highly selective inhibitor of IRAK4 kinase activity that demonstrates equipotent activity against multiple MyD88-dependent responses both in vitro and in v...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Dudhgaonkar, Shailesh, Ranade, Sourabh, Nagar, Jignesh, Subramani, Siva, Prasad, Durga Shiv, Karunanithi, Preethi, Srivastava, Ratika, Venkatesh, Kamala, Selvam, Sabariya, Krishnamurthy, Prasad, Mariappan, T. Thanga, Saxena, Ajay, Fan, Li, Stetsko, Dawn K., Holloway, Deborah A., Li, Xin, Zhu, Jun, Yang, Wen-Pin, Ruepp, Stefan, Nair, Satheesh, Santella, Joseph, Duncia, John, Hynes, John, McIntyre, Kim W., Carman, Julie A.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2017
Assuntos:
Innate Immunity and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253435/
https://ncbi.nlm.nih.gov/pubmed/28003376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600583
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