Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity

The serine/threonine kinase IL-1R–associated kinase (IRAK)4 is a critical regulator of innate immunity. We have identified BMS-986126, a potent, highly selective inhibitor of IRAK4 kinase activity that demonstrates equipotent activity against multiple MyD88-dependent responses both in vitro and in v...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Immunol
Prif Awduron: Dudhgaonkar, Shailesh, Ranade, Sourabh, Nagar, Jignesh, Subramani, Siva, Prasad, Durga Shiv, Karunanithi, Preethi, Srivastava, Ratika, Venkatesh, Kamala, Selvam, Sabariya, Krishnamurthy, Prasad, Mariappan, T. Thanga, Saxena, Ajay, Fan, Li, Stetsko, Dawn K., Holloway, Deborah A., Li, Xin, Zhu, Jun, Yang, Wen-Pin, Ruepp, Stefan, Nair, Satheesh, Santella, Joseph, Duncia, John, Hynes, John, McIntyre, Kim W., Carman, Julie A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: AAI 2017
Pynciau:
Innate Immunity and Inflammation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253435/
https://ncbi.nlm.nih.gov/pubmed/28003376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600583
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