Novel Replication-Incompetent Vector Derived from Adenovirus Type 11 (Ad11) for Vaccination and Gene Therapy: Low Seroprevalence and Non-Cross-Reactivity with Ad5

A novel plasmid-based adenovirus vector system that enables manufacturing of replication-incompetent (ΔE1) adenovirus type 11 (Ad11)-based vectors is described. Ad11 vectors are produced on PER.C6/55K cells yielding high-titer vector batches after purification. Ad11 seroprevalence proves to be signi...

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Bibliografiske detaljer
Main Authors: Holterman, Lennart, Vogels, Ronald, van der Vlugt, Remko, Sieuwerts, Martijn, Grimbergen, Jos, Kaspers, Jorn, Geelen, Eric, van der Helm, Esmeralda, Lemckert, Angelique, Gillissen, Gert, Verhaagh, Sandra, Custers, Jerome, Zuijdgeest, David, Berkhout, Ben, Bakker, Margreet, Quax, Paul, Goudsmit, Jaap, Havenga, Menzo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Gene Therapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC525025/
https://ncbi.nlm.nih.gov/pubmed/15542673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.23.13207-13215.2004
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