Novel Replication-Incompetent Vector Derived from Adenovirus Type 11 (Ad11) for Vaccination and Gene Therapy: Low Seroprevalence and Non-Cross-Reactivity with Ad5

A novel plasmid-based adenovirus vector system that enables manufacturing of replication-incompetent (ΔE1) adenovirus type 11 (Ad11)-based vectors is described. Ad11 vectors are produced on PER.C6/55K cells yielding high-titer vector batches after purification. Ad11 seroprevalence proves to be signi...

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Detaylı Bibliyografya
Asıl Yazarlar: Holterman, Lennart, Vogels, Ronald, van der Vlugt, Remko, Sieuwerts, Martijn, Grimbergen, Jos, Kaspers, Jorn, Geelen, Eric, van der Helm, Esmeralda, Lemckert, Angelique, Gillissen, Gert, Verhaagh, Sandra, Custers, Jerome, Zuijdgeest, David, Berkhout, Ben, Bakker, Margreet, Quax, Paul, Goudsmit, Jaap, Havenga, Menzo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2004
Konular:
Gene Therapy
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC525025/
https://ncbi.nlm.nih.gov/pubmed/15542673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.23.13207-13215.2004
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