Novel Replication-Incompetent Vector Derived from Adenovirus Type 11 (Ad11) for Vaccination and Gene Therapy: Low Seroprevalence and Non-Cross-Reactivity with Ad5

A novel plasmid-based adenovirus vector system that enables manufacturing of replication-incompetent (ΔE1) adenovirus type 11 (Ad11)-based vectors is described. Ad11 vectors are produced on PER.C6/55K cells yielding high-titer vector batches after purification. Ad11 seroprevalence proves to be signi...

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Detalhes bibliográficos
Main Authors: Holterman, Lennart, Vogels, Ronald, van der Vlugt, Remko, Sieuwerts, Martijn, Grimbergen, Jos, Kaspers, Jorn, Geelen, Eric, van der Helm, Esmeralda, Lemckert, Angelique, Gillissen, Gert, Verhaagh, Sandra, Custers, Jerome, Zuijdgeest, David, Berkhout, Ben, Bakker, Margreet, Quax, Paul, Goudsmit, Jaap, Havenga, Menzo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC525025/
https://ncbi.nlm.nih.gov/pubmed/15542673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.23.13207-13215.2004
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