The Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating Cystic Fibrosis Transmembrane Conductance Regulator Inhibition by Cigarette Smoke

Acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction may contribute to chronic obstructive pulmonary disease pathogenesis and is a potential therapeutic target. We sought to determine the acute effects of cigarette smoke on ion transport and the mucociliary transport appar...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Raju, S. Vamsee, Lin, Vivian Y., Liu, Limbo, McNicholas, Carmel M., Karki, Suman, Sloane, Peter A., Tang, Liping, Jackson, Patricia L., Wang, Wei, Wilson, Landon, Macon, Kevin J., Mazur, Marina, Kappes, John C., DeLucas, Lawrence J., Barnes, Stephen, Kirk, Kevin, Tearney, Guillermo J., Rowe, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248967/
https://ncbi.nlm.nih.gov/pubmed/27585394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0226OC
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