Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: Influence of osteotropic factors

BACKGROUND: Osteoarthritis (OA) is the most common human joint disease. Recent studies suggest that an abnormal subchondral bone metabolism is intimately involved in the genesis of this disease. Bone remodelling is tightly regulated by a molecular triad composed of OPG/RANK/RANKL. RANKL exists as 3...

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Bibliographische Detailangaben
Veröffentlicht in:Bone
Hauptverfasser: Tat, Steeve Kwan, Pelletier, Jean-Pierre, Lajeunesse, Daniel, Fahmi, Hassan, Duval, Nicolas, Martel-Pelletier, Johanne
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247263/
https://ncbi.nlm.nih.gov/pubmed/18539107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2008.04.006
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